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identifier: 1349535
description:
epitope description:EAFIKTAAAETFLAW
antigen name:Erythrocyte membrane protein 1, PfEMP1 (UniProt:Q8I220)
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 16299291
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003094
landingPage: http://www.iedb.org/assay/1349535
type:
Literature
publicationVenue:
Infect Immun
dates:
2005
study type: b cell assays
subject species: Plasmodium falciparum
fullName:
Kim Brustoski
Martin Kramer
Ulrike Mö
ller
Peter G Kremsner
Adrian J F Luty
method:
ELISA
name:
Neonatal and maternal immunological responses to conserved epitopes within the DBL-gamma3 chondroitin sulfate A-binding domain of Plasmodium falciparum erythrocyte membrane protein 1.
description:
This sequence is confirmed by the authors to be used in the assays, even when the sequence presented in the manuscript has a T instead of I listed at position 4.
The proportion of cord blood samples positive for IgM specificity towards this peptide is higher from neonates whose mothers had P.falciparum-positive placental tissue than those that were treated for P.falciparum infection or were exposed but with negative placental infection. The mothers of all 3 groups also had levels of IgM, and IgG, to this peptide above non-exposed controls.

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