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Title: Immunological cross-reactivity between preS2 sequences of the hepatitis B virus envelope proteins corresponding to serological subtypes adw2 and ayw.
identifier: 1349586
description:
epitope description:MQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTVNP
antigen name:Large envelope protein
host organism:Oryctolagus cuniculus
antibody name:Anti-HBsAg
aggregation:
instance of dataset
availability:
available
primaryPublications: 3657796
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003160
landingPage: http://www.iedb.org/assay/1349586
type:
Literature
publicationVenue:
Mol Immunol
dates:
1987
study type: b cell assays
subject species: Hepatitis B virus subtype ayw
fullName:
A R Neurath
S B Kent
P Adamowicz
M M Riottot
P Price
N Strick
K Parker
M A Petit
A Budkowska
M Girard
et al.
method:
radio immuno assay (RIA)
name:
Immunological cross-reactivity between preS2 sequences of the hepatitis B virus envelope proteins corresponding to serological subtypes adw2 and ayw.
description:
The epitope was capable of inhibiting the binding of preS2(ayw)-beta-gal with rabbit HBsAg-specific antisera. The determination of inhibitor concentrations, at which the binding of preS2(ayw)-beta-gal was reduced to 50%, allowed the calculation of the average antibody affinity constant (K) [3.2x107 1/mol]. A further analysis of affinity constants using a double-antibody assay confirmed the subtype specificity of the antisera-epitope intreaction.

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