Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes.

Title:

Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes.

Dataset

identifier:	1350832
description:	epitope description:LQDPRVRGLYFPAGG antigen name:Large envelope protein host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	2480595

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003226
landingPage:	http://www.iedb.org/assay/1350832

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	1989

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus

Person

fullName:	J P Tam Y A Lu

Data Type

method:	ELISA

Study

name:	Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes.
description:	Different models were designed to produce MAPs containing the epitope. In the heterologous branching model, 4 copies of two different antigens were attached to the same octabranching MAP to give a diepitope MAP with a design of alternating antigens. For comparison, the dimer was also tested resulting in a similar response.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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