Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.

Title:

Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.

identifier:	1351320
description:	epitope description:KNAAKLRGDLRQWVSAG antigen name:UniProt:B8ZU53 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7505263

study type:	b cell assays
subject species:	Mycobacterium leprae

fullName:	S Singh N P Narayanan P J Jenner G Ramu M J Colston H K Prasad I Nath

method:	ELISA

name:	Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.
description:	Sera from 59.0% of patients with erythema nodosum leprosum (ENL), 47.9% of lepromatous leprosy patients with a history of reaction or 32.8% of those with stable infection, 42.8% of tuberculoid leprosy patients, and 16.6% of healthy leprosy household contacts reacted with the epitope by ELISA. The RGD motif was shown to play a role in recognition as peptides with this motif at the end of the peptide had enhanced binding as compared to this epitope with RGD in the middle.

name:	iedb
homePage:	http://www.iedb.org

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