Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.

Title:

Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.

identifier:	1351323
description:	epitope description:LRGDLRQWVSAGRRVG antigen name:UniProt:B8ZU53 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7505263

study type:	b cell assays
subject species:	Mycobacterium leprae

fullName:	S Singh N P Narayanan P J Jenner G Ramu M J Colston H K Prasad I Nath

method:	ELISA

name:	Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein.
description:	Sera from 81.8% of patients with erythema nodosum leprosum (ENL), 12.5% of lepromatous leprosy patients with a history of reaction or 48.8% of those with stable infection, 55.8% of tuberculoid leprosy patients, and 44.4% of healthy leprosy household contacts reacted with the epitope by ELISA. The RGD motif was shown to play a role in recognition as peptides with this motif deleted or in the middle of the peptide had decreased binding as compared to this epitope with RGD at the end of the sequence.

name:	iedb
homePage:	http://www.iedb.org

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