Stimulation of a memory B cell response does not require primed helper T cells. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Stimulation of a memory B cell response does not require primed helper T cells.

Dataset

identifier:	1353461
description:	epitope description:QDPRVRGLYFPAGG antigen name:Large envelope protein host organism:Mus musculus DBA/1
aggregation:	instance of dataset
availability:	available
primaryPublications:	7589122

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003018
landingPage:	http://www.iedb.org/assay/1353461

Publication

type:	Literature
publicationVenue:	Eur J Immunol
dates:	1995

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus

Person

fullName:	C Leclerc C Sedlik R Lo-Man B Charlot M Rojas E Dé riaud

Data Type

method:	ELISA

Study

name:	Stimulation of a memory B cell response does not require primed helper T cells.
description:	Sera from mice immunized with the epitope reacted with a peptide fragment, preS 120-145, containing the epitope. The response was primarily IgG with IgM undetectable. Enhancement due to priming with the T helper epitope contained within residues 120-132 was studied through pre-immunization with the T helper epitope or immunization with a peptide containing both the epiope and the T helper epitope. The greatest antibody response was observed when preS 120-145, containing both the B and T cell epitopes, was used as both immunogen and boost, demonstrating memory B cells were responsible for this response.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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