Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

Title:

Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

identifier:	1353966
description:	epitope description:HQLDPAFGAN antigen name:Large envelope protein host organism:Mus musculus antibody name:18/7, 116-8
aggregation:	instance of dataset
availability:	available
primaryPublications:	9356343

study type:	b cell assays
subject species:	Hepatitis B virus subtype adw2

fullName:	F D'Mello C D Partidos M W Steward C R Howard

method:	ELISA

name:	Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.
description:	This sequence is recognized by 2 mAbs in a PEPSCAN analysis, one of which also recognized a different peptide of HBsAg, residues 131-142 in the Pre-S2 region. Pepscan analysis of overlapping peptides covering the pre-S region of HBsAg adw2 allowed for the determination of this region as involved in the epitope recognized by 2 mAbs, one raised against the ay and the other to the ad subtype.

name:	iedb
homePage:	http://www.iedb.org

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