Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

Title:

Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

identifier:	1354033
description:	epitope description:LLDPSFDYFQLYTT host organism:Mus musculus antibody name:18/7
aggregation:	instance of dataset
availability:	available
primaryPublications:	9356343

study type:	b cell assays
subject species:

fullName:	F D'Mello C D Partidos M W Steward C R Howard

method:	antigen inhibition

name:	Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.
description:	This peptide was derived from a phage display library for its binding to an anti-HBsAg mAb shown to recognize regions 28-37 and 131-142 of the pre-S region. This mimotope shares the motif DPXF with residues 31-34 and with other peptides recognized by the mAb. The peptide (isolated or phage displayed) is shown to inhibit the binding of its selecting mAb to HBsAg particles coated on the solid-phase in an competitive inhibition ELISA.

name:	iedb
homePage:	http://www.iedb.org

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