Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

Title:

Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.

identifier:	1354038
description:	epitope description:LLDPSFDYFQLYTT host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	9356343

study type:	b cell assays
subject species:

fullName:	F D'Mello C D Partidos M W Steward C R Howard

method:	ELISA

name:	Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries.
description:	This peptide was derived from a phage display library for its binding to an anti-HBsAg mAb shown to recognize regions 28-37 and 131-142 of the pre-S region. This mimotope shares the motif DPXF with residues 31-34 and with other peptides recognized by the mAb. Mice immunized with the peptide (either phage displayed or as a free peptide coadministered with a Thelper peptide) show similar titers to the immunogenic peptide than to a peptide corresponding to residues 20-45 of pre-S HBsAg containing the region it was deduced to mimic based on their sequence similarities. Also the sera is able to recognize the complete Pre-S HBsAg protein.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.