Identifying epitopes responsible for neutralizing antibody and DC-SIGN binding on the spike glycoprotein of the severe acute respiratory syndrome coronavirus.

Title:

Identifying epitopes responsible for neutralizing antibody and DC-SIGN binding on the spike glycoprotein of the severe acute respiratory syndrome coronavirus.

Dataset

identifier:	1368899
description:	epitope description:NYNWKR host organism:Mus musculus BALB/c antibody name:SIb4
aggregation:	instance of dataset
availability:	available
primaryPublications:	17041212

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003570
landingPage:	http://www.iedb.org/assay/1368899

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2006

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Yi-Ping Shih Chia-Yen Chen Shih-Jen Liu Kuan-Hsuan Chen Yuan-Ming Lee Yu-Chan Chao Yi-Ming Arthur Chen

Data Type

method:	ELISA

Study

name:	Identifying epitopes responsible for neutralizing antibody and DC-SIGN binding on the spike glycoprotein of the severe acute respiratory syndrome coronavirus.
description:	The sequence from a phage display library shares 4 amino acids with a SARS peptide, NYNWK. Overlapping peptides were used to map the epitope, and the epitope-specific mAb was able to bind to a fragment of the SARS S protein by ELISA

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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