Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities.

Title:

Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities.

Dataset

identifier:	1369141
description:	epitope description:GFAPDLQ + AMID(G1) host organism:Mus musculus antibody name:282, 283, 287
aggregation:	instance of dataset
availability:	available
primaryPublications:	12538696

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003488
landingPage:	http://www.iedb.org/assay/1369141

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2003

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Deepak T Nair Kanwal J Kaur Kavita Singh Paushali Mukherjee Deepa Rajagopal Anna George Vineeta Bal Satyajit Rath Kanury V S Rao Dinakar M Salunke

Data Type

method:	antigen inhibition

Study

name:	Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities.
description:	This retroinverso analog (i.e, of d aminoacids of the inverse sequence) of the HBV peptide QLDPAFG is synthesized with its N-terminus acetylated and the C-terminus amidated, since the inversion of polarity at the termini could affect its biding interactions. The retro-inverso analog of the 7-mer QLDPAFG is unable to inhibit the binding of previously characterized mAbs to the cognate QLDPAFG-containing 15 mer HQLDPAFGANSTNPD.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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