Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1003243 |
| landingPage: |
http://www.iedb.org/assay/1356636 |
| type: |
Literature
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| publicationVenue: |
Microbes Infect
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| dates: |
2005
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| study type: | b cell assays |
| subject species: | Plasmodium falciparum |
| fullName: |
Ivette Caro-Aguilar
Stacey Lapp
Jan Pohl
Mary R Galinski
Alberto Moreno
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| method: |
ELISA
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| name: |
Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria.
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| description: |
No specific accession number is given by the authors. The epitope is repeated multiple times within the circumsporozoite protein.
Mice were immunized with a peptide containing the epitope plus a promiscuous helper T cell epitope (either PvT19 or PvT53) from plasmodium vivax. Immunization with either peptide failed to induce a serum Ab response against the PfB epitope. The PfB epitope used in the assay contained a cysteine residue on both the N- and C-termini to enhance polymerization and adsorption to the ELISA plate. Sera were pooled from 4 mice.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
