Identification of hepatitis A virus mimotopes by phage display, antigenicity and immunogenicity. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification of hepatitis A virus mimotopes by phage display, antigenicity and immunogenicity.

Dataset

identifier:	1368152
description:	epitope description:SHSVTKSLRVFGGPP host organism:Homo sapiens antibody name:anti-HAV
aggregation:	instance of dataset
availability:	available
primaryPublications:	17129616

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003558
landingPage:	http://www.iedb.org/assay/1368152

Publication

type:	Literature
publicationVenue:	J Virol Methods
dates:	2007

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Osmany G Larralde Raiza Martinez Frank Camacho Nevis Amin Alicia Aguilar Arturo Talavera David I Stott Ela M Perez

Data Type

method:	ELISA

Study

name:	Identification of hepatitis A virus mimotopes by phage display, antigenicity and immunogenicity.
description:	The peptide has limited sequence homology to hepatitis A virus VP3 and VP1 capsid proteins. The epitope was identified from one round of immunoselection with serum from a convalescent viral hepatitis A patient used on a phage display library of random nonapeptides fused to the N-terminus of the phage pIII capsid protein. The epitope was recognized by 26 of 28 sera from convalescent viral hepatitis A patients and one serum sample from a donor immunized with HAVRIX hepatitis A vaccine. The epitope had discontinuous sequence similarity to residues 69-83 (SDSVGQQIKVIPVDP) of VP3 capsid protein and residues 14-16 (SVT) and residues in the region 221-227 (KTDSTFG) of VP1 from HAV (strain HM-175).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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