A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

Title:

A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

Dataset

identifier:	1368337
description:	epitope description:PAFRANTANPDWDFNPNKDTWP antigen name:Large envelope protein host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	2438344

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003186
landingPage:	http://www.iedb.org/assay/1368337

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1987

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus subtype ayw

Person

fullName:	D R Milich A McLachlan A Moriarty G B Thornton

Data Type

method:	radio immuno assay (RIA)

Study

name:	A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.
description:	This peptide from the HBsAg of ayw subtype has 5 substitutions in the adw2 subtype: R4G, T7S, A8N, N17V, T20D. IgG of B10, B10.BR and B10.M mice recognize the peptide p32-53/y after immunization with Large HBsAg of adw2 subtype, implying cross reaction at this peptide level between the 2 subtypes.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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