A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

Title:

A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

Dataset

identifier:	1368814
description:	epitope description:PASTNRQSGRQP antigen name:Large envelope protein host organism:Mus musculus SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	2438344

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003186
landingPage:	http://www.iedb.org/assay/1368814

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1987

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus subtype adw2

Person

fullName:	D R Milich A McLachlan A Moriarty G B Thornton

Data Type

method:	radio immuno assay (RIA)

Study

name:	A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.
description:	This peptide from the HBsAg of ayw subtype is also found conserved in the adw2 subtype. No significant IgG recognition of this peptide is obtained in SJL/J mice after immunization with a suboptimal dose of preS2-containing (Large) HBsAg, but priming the response with the longer peptide 94-117, able to function as a T helper epitope, enhances the response to this peptide. Priming with T helper epitope 12-32 did not enhance the response. The response cannot therefore be attributed solely to the T helper function of the longer peptide since it also primed B cells relevant to this peptide.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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