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Title: Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.
identifier: 1369736
description:
epitope description:LKANAAGKDKGVEELEKLSGSLESLSKAAKEMLANSVKELTS
antigen name:UniProt:C0R7B3
host organism:Mus musculus C3H/He
antibody name:Anti-ABKD sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 16996663
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003651
landingPage: http://www.iedb.org/assay/1369736
type:
Literature
publicationVenue:
Vaccine
dates:
2007
study type: b cell assays
subject species: Borreliella burgdorferi
fullName:
Christopher G Earnhart
Eric L Buckles
Richard T Marconi
method:
ELISA
name:
Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.
description:
Mice immunized with the chimeric OspC ABKD vaccinogen (four epitope construct) generated antisera capable of reacting with the individual OspC proteins of types A, B, K and D. Significant differences in the antibody titer to individual epitopes were observed. Epitope-specific titers also decreased with its proximity to the C-terminus of the chimeric vaccinogen.

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