Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1.

Title:

Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1.

identifier:	1369712
description:	epitope description:SPAFTKGEKVDLN antigen name:UniProt:D6SEW7 host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	17131300

study type:	b cell assays
subject species:	Staphylococcus aureus

fullName:	Alfonso Bavoso Angela Ostuni Jolanda De Vendel Francesco Pollaro Francesca Armentano Thomas Knight Sudesh Makker Alfonso Tramontano

method:	biological activity

name:	Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1.
description:	Carbonyl tags were introduced to the immunizing peptide by Amadori reaction with glycolaldehyde, and the aldehyde-modified peptide was used to immunize rabbits. The ability of antiserum to neutralize the biological activity ofTSST-1 was assessed by its effect on the superantigen induced proliferation of mouse splenocytes. Stimulationin the presence of TSST-1 was not inhibited in the presence of the antiserum generated to the modified peptide.

name:	iedb
homePage:	http://www.iedb.org

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