Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity.

Title:

Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity.

Dataset

identifier:	1370131
description:	epitope description:VTGTDLELIQILK antigen name:Capsid protein VP1 host organism:Homo sapiens antibody name:MAb 1418-1
aggregation:	instance of dataset
availability:	available
primaryPublications:	17020940

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003649
landingPage:	http://www.iedb.org/assay/1370131

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2006

Dimension

study type:	b cell assays
subject species:	Human parvovirus B19 genotype 1

Person

fullName:	Carlos Ros Marco Gerber Christoph Kempf

Data Type

method:	biological activity

Study

name:	Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity.
description:	MAb 1418-1 sequence recognition confirmed from other paper (J. Gen. Virol. 82:191-199). Results suggest that MAb 1418-1 binds and neutralizes the virus following putative capsid rearrangement (which exposes VP1u) induced by cell receptor attachment. MAb 1418-1 was previously found to recognize residues 30-42 of the VP1u protein (VTGTDLELIQILK).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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