Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA.

Title:

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA.

identifier:	1370857
description:	epitope description:KNEKKCINSKSGQGDKIQGACKRKCEK antigen name:Erythrocyte membrane protein 1, PfEMP1 (UniProt:Q8I639) host organism:Homo sapiens antibody name:PAM 8.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	17176260

study type:	b cell assays
subject species:	Plasmodium falciparum FCR-3/Gambia

fullName:	Lea Barfod Nadia L Bernasconi Madeleine Dahlbä ck David Jarrossay Pernille Haste Andersen Ali Salanti Michael F Ofori Louise Turner Mafalda Resende Morten A Nielsen Thor G Theander Federica Sallusto Antonio Lanzavecchia Lars Hviid

method:	western blot

name:	Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA.
description:	The chimeric protein where this region from a mAb PAM 8.1-reactive protein was grafted in the scaffold of a variant not reactive with the mAb still retains its reactivity, suggesting this region contains the epitope for that mAb. .

name:	iedb
homePage:	http://www.iedb.org

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