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Title: Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
identifier: 1372631
description:
epitope description:KNGLENYAYSMKNTLSDSNV
antigen name:Putative heat-shock protein hsp70
host organism:Homo sapiens
antibody name:patient sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 9840686
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003754
landingPage: http://www.iedb.org/assay/1372631
type:
Literature
publicationVenue:
Immunol Lett
dates:
1998
study type: b cell assays
subject species: Leishmania infantum
fullName:
L Quijada
J M Requena
M Soto
C Alonso
method:
ELISA
name:
Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
description:
The sequence is from the reference: Quijada et al. (1996) Immunol. Letts. 52: 73-79.
Sera from 4 of 5 patients with visceral leishmaniasis reacted with the epitope. Five VL patient sera that recognized L. infantum Hsp70 were screened against a panel of overlapping 20-mer peptides spanning the sequence of L. infantum Hsp70. The epitope is contained within one of two main antigenic regions (residues 241-335 and 496-653) of the molecule.

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