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Title: Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
identifier: 1372639
description:
epitope description:VCNPIMTKMYQSMGGAAGGMPGGMPGMSGMSGGAGPAGGASSGPKVEEVD
antigen name:Putative heat-shock protein hsp70
host organism:Homo sapiens
antibody name:patient sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 9840686
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003754
landingPage: http://www.iedb.org/assay/1372639
type:
Literature
publicationVenue:
Immunol Lett
dates:
1998
study type: b cell assays
subject species: Leishmania infantum
fullName:
L Quijada
J M Requena
M Soto
C Alonso
method:
ELISA
name:
Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
description:
The sequence is from the reference: Quijada et al. (1996) Immunol. Letts. 52: 73-79.
Sera from 5 of 5 patients with visceral leishmaniasis reacted with the epitope. The epitope is contained within one (residues 496-653) of two main antigenic regions identified by screening 5 VL patient sera against a panel of overlapping 20-mer peptides spanning the sequence of L. infantum Hsp70. Among serum samples with reactivity against recombinant L. infantum Hsp70, 36% reacted with the epitope.

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