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Title: Antigenicity and conformational analysis of the Zn(2+)-binding sites of two Zn(2+)-metalloproteases: Leishmania gp63 and mammalian endopeptidase-24.11.
identifier: 1372791
description:
epitope description:VVTHEMAHALG
antigen name:GP63, leishmanolysin (UniProt:Q4QHH2)
host organism:Oryctolagus cuniculus New Zealand White
antibody name:anti-pepgp63
aggregation:
instance of dataset
availability:
available
primaryPublications: 8573078
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003766
landingPage: http://www.iedb.org/assay/1372791
type:
Literature
publicationVenue:
Biochem J
dates:
1996
study type: b cell assays
subject species: Leishmania major
fullName:
K P Soteriadou
A K Tzinia
E Panou-Pamonis
V Tsikaris
M Sakarellos-Daitsiotis
C Sakarellos
Y Papapoulou
R Matsas
method:
ELISA
name:
Antigenicity and conformational analysis of the Zn(2+)-binding sites of two Zn(2+)-metalloproteases: Leishmania gp63 and mammalian endopeptidase-24.11.
description:
Residues His4 and Glu5 of epitope (VVTHEMAHALG) are involved in antibody binding. Antibody binding was tested for multiple shorter peptides derived from the epitope. The shortest peptide capable of significant antibody binding was the pentapeptide VVTHE. However, highest binding was observed with the full-length epitope.

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