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Title: Identification of continuous B-cell epitopes on the protein moiety of the 58-kiloDalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens.
identifier: 1373112
description:
epitope description:HTHADGEVHC
antigen name:pH-regulated antigen PRA1
host organism:Mus musculus BALB/c
antibody name:anti-C-terminal peptide (290-299) sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 11292706
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003833
landingPage: http://www.iedb.org/assay/1373112
type:
Literature
publicationVenue:
Infect Immun
dates:
2001
study type: b cell assays
subject species: Candida albicans
fullName:
A Viudes
S Perea
J L Lopez-Ribot
method:
ELISA
name:
Identification of continuous B-cell epitopes on the protein moiety of the 58-kiloDalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens.
description:
Mice immunized with the epitope-KLH conjugate reacted with the epitope in a dose-dependent fashion. The epitope in solution inhibited the the binding of the anti-C-terminal peptide sera to the epitope. PepScan analyses with a panel of overlapping dodecapeptides or octapeptides spanning the sequence of the C. albicans mp58 protein showed that reactivity of the anti-peptide sera was limited to peptides from the C-terminal region (NSHCHTHADGEV, HCHTHADGEVHC, THADGEVH, and HADGEVHC).

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