Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.

Title:

Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.

identifier:	1376705
description:	epitope description:KQHTVTTTTKGE antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:VRQ14
aggregation:	instance of dataset
availability:	available
primaryPublications:	15240887

study type:	b cell assays
subject species:	Ovis aries

fullName:	Fré dé ric Eghiaian Jeanne Grosclaude Sté phanie Lesceu Pascale Debey Bé né dicte Doublet Eric Tré guer Human Rezaei Marcel Knossow

method:	ELISA

PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.-->

name:	Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.
description:	The epitope specific mAb VRQ14 recognized both infected and uninfected brain homogenates from sheep, mouse, hamster and macaque. The mAb did not react with Prnp(0/0) mouse brain homogenates, which lack Prp.

name:	iedb
homePage:	http://www.iedb.org

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