Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies.

Title:

Dataset

identifier:	1793247
description:	epitope description:KFPED antigen name:Thyroid peroxidase (UniProt:P07202) host organism:Mus musculus BALB/c antibody name:mAb 47
aggregation:	instance of dataset
availability:	available
primaryPublications:	15150267

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017296
landingPage:	http://www.iedb.org/assay/1793247

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2004

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Damien Bresson Martine Pugniè re Franç oise Roquet Sandra A Rebuffat Brigitte N-Guyen Martine Cerutti Jin Guo Sandra M McLachlan Basil Rapoport Valé rie Estienne Jean Ruf Thierry Chardè s Sylvie Pé raldi-Roux

Data Type

method:	western blot

Study

name:	Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies.
description:	The epitope-specific mAb bound to a Thyroid peroxidase peptide, and the critical amino acids K1, P3, and E4, were determined by alanine scan.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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