Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their inner epitopes and results in conjugate vaccines having improved immunological properties.

Title:

Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their inner epitopes and results in conjugate vaccines having improved immunological properties.

Dataset

identifier:	1789812
description:	epitope description:N. meningiditis L7 lipoundecasaccharide antigen name:lipooligosaccharide host organism:Mus musculus CF-1
aggregation:	instance of dataset
availability:	available
primaryPublications:	12526840

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008027
landingPage:	http://www.iedb.org/assay/1789812

Publication

type:	Literature
publicationVenue:	Carbohydr Res
dates:	2003

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis M982B

Person

fullName:	Malgorzata Mieszala Grigorij Kogan Harold J Jennings

Data Type

method:	biological activity

Study

name:	Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their inner epitopes and results in conjugate vaccines having improved immunological properties.
description:	Antibodies were IgG2a, IgG2b and IgG3 isotype. Anti-epitope sera exhibited bactericidal activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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