Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

Dataset

identifier:	1789815
description:	epitope description:FAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:A-887755, A887756
aggregation:	instance of dataset
availability:	available
primaryPublications:	20685980

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020946
landingPage:	http://www.iedb.org/assay/1789815

Publication

type:	Literature
publicationVenue:	J Neurosci
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Heinz Hillen Stefan Barghorn Andreas Striebinger Boris Labkovsky Reinhold Mü ller Volker Nimmrich Marc W Nolte Claudia Perez-Cruz Ingrid van der Auwera Fred van Leuven Marcel van Gaalen Anton Y Bespalov Hans Schoemaker James P Sullivan Ulrich Ebert

Data Type

method:	antigen inhibition

Study

name:	Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.
description:	The epitope-specific mAb A-887755 was able to neutralize amyloid beta oligomer-derived neuro-pathologies in rat primary hippocampal neurons, and the epitope was able to compete for this binding and reduce the protection. The epitope specific mAbs A-88755 and A887756 were also shown to bind to the epitope in a Western blot

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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