Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1019537 |
| landingPage: |
http://www.iedb.org/assay/1790093 |
| type: |
Literature
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| publicationVenue: |
Ophthalmic Res
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| dates: |
1992
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| study type: | b cell assays |
| subject species: |
| fullName: |
A Leonardi
A G Secchi
R Briggs
M R Allansmith
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| method: |
in vivo skin test
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| name: |
Conjunctival mast cells and the allergic late phase reaction.
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| description: |
Immunized guinea pigs had an immediate anaphylactic reaction in the eyes challenged with the epitope-lysine conjugate versus no reaction in the contralateral eyes challenged with PBS. Overall the clinical score was greatest at 0.5 hr and declined at 9 and 24 hr. Individually the response varied and one third each of the animals showed a pattern of waxing and waning, a biphasic response, or a prolonged progressively decreasing reaction over 9-12 hr. Histological analyses showed that 95% of the mast cells of the conjunctival stroma in the epitope-treated eyes were degranulated at 0.5 hr and the number of inflammatory cells in the conjunctival substantia propria was significantly increased compared to the control eyes over the 0.5 to 24 hr time course.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
