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Title: Induction of eczematous skin reaction in experimentally induced hyperplastic skin of Balb/C mice by monoclonal anti-DNP IgE antibody: possible implications for skin lesion formation in atopic dermatitis.
identifier: 1790096
description:
epitope description:2,4-dinitrophenyl group
host organism:Mus musculus
aggregation:
instance of dataset
availability:
available
primaryPublications: 1983077
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1019541
landingPage: http://www.iedb.org/assay/1790096
type:
Literature
publicationVenue:
Int Arch Allergy Appl Immunol
dates:
1990
study type: b cell assays
subject species:
fullName:
I Katayama
R
H Yokozeki
K Nishioka
Y Dohi
method:
in vivo skin test
name:
Induction of eczematous skin reaction in experimentally induced hyperplastic skin of Balb/C mice by monoclonal anti-DNP IgE antibody: possible implications for skin lesion formation in atopic dermatitis.
description:
Transfer of monoclonal anti-DNP IgE antibodies induced a biphasic skin reaction in recipients with an early (1 h) and late (24 h) response peak. Genetically mast cell-deficient W/Wvv mice did not show an early or late skin reaction, demonstrating that mast cells are required for IgE-mediated skin reactions. Anti-DNP IgE antibodies induced focal eczematous skin reactions with spongiosis, mast cell degranulation, and mononuclear cell infiltration in retinoic acid pre-treated mice in response to DNFB.

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