Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3).

Title:

Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3).

identifier:	1790143
description:	epitope description:cardiolipin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	1569194

study type:	b cell assays
subject species:

fullName:	R Bakimer P Fishman M Blank B Sredni M Djaldetti Y Shoenfeld

method:	antigen inhibition

name:	Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3).
description:	Adoptive transfer of the cardiolipin-specific human mAb H-3 into naive mice induced the production of high titer anti-cardiolipin antibodies (ACA). ACA were measured by inhibition assay in which the binding of sera to cardiolipin were inhibited by cardiolipin in solution, and by direct ELISA. ACA also inhibited the binding of sera to DNA, as well as platelets.

name:	iedb
homePage:	http://www.iedb.org

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