Determination of the epitope specificity of monoclonal antibodies against the inner core region of bacterial lipopolysaccharides by use of 3-deoxy-D-manno-octulosonate-containing synthetic antigens.

Title:

Determination of the epitope specificity of monoclonal antibodies against the inner core region of bacterial lipopolysaccharides by use of 3-deoxy-D-manno-octulosonate-containing synthetic antigens.

Dataset

identifier:	1790241
description:	epitope description:3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid antigen name:lipopolysaccharide host organism:Mus musculus BALB/c antibody name:Clone 20
aggregation:	instance of dataset
availability:	available
primaryPublications:	2482126

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011079
landingPage:	http://www.iedb.org/assay/1790241

Publication

type:	Literature
publicationVenue:	Carbohydr Res
dates:	1989

Dimension

study type:	b cell assays
subject species:	Salmonella enterica subsp. enterica serovar Minnesota R595

Person

fullName:	A Rozalski L Brade H M Kuhn H Brade P Kosma B J Appelmelk S Kusumoto H Paulsen

Data Type

method:	antigen inhibition

Study

name:	Determination of the epitope specificity of monoclonal antibodies against the inner core region of bacterial lipopolysaccharides by use of 3-deoxy-D-manno-octulosonate-containing synthetic antigens.
description:	The antigen inhibited passive-hemolysis of epitope-specific mAb. Structures [alpha-KDO-(2→4)-ß-KDO]n-PA, [alpha-KDO-(2→8)-alpha-KDO]n-PA, [ß-KDO-(2→8)-alpha-KDO]n-PA, [alpha-KDO-(2→4)-alpha-5d-KDO]n-PA, [alpha-KDO-(2→7)-alpha-KDO]n-PA, [alpha-KDO-(2→4)-alpha-KDO-(2→4)-alpha-KDO]n-PA, [alpha-KDO-(2→4)-ß-KDO-(2→4)-alpha-KDO]n-PA, and [alpha-KDO-(2→8)-alpha-KDO-(2→4)-alpha-KDO]n-PA all showed positive inhibition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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