Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice.

Title:

Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice.

Dataset

identifier:	1791586
description:	epitope description:N-glycoloyl-beta-neuraminic acid antigen name:glycosphingolipid host organism:Mus musculus C57BL/6 CMAH null
aggregation:	instance of dataset
availability:	available
primaryPublications:	20173026

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019279
landingPage:	http://www.iedb.org/assay/1791586

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Hiroyuki Tahara Kentaro Ide Nabin Bahadur Basnet Yuka Tanaka Haruo Matsuda Hiromu Takematsu Yasunori Kozutsumi Hideki Ohdan

Data Type

method:	flow cytometry

Study

name:	Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice.
description:	Production of anti-NeuGc IgG was observed a few months postimmunization of cytidine monophospho–N-acetylneuraminic acid hydroxylase (CMAH) deficient (CMHA-/-) B6 mice with xenogeneic rat thymocytes (predominant subclasses were IgG1 and IgG3) indicating that class switching of Ig occurs with anti-NeuGc specificity. The reactivity to the epitope by immunized mice IgG was also found on CMHA+/+ pancreatic islets.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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