Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019279 |
| landingPage: |
http://www.iedb.org/assay/1791588 |
| type: |
Literature
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| publicationVenue: |
J Immunol
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| dates: |
2010
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| study type: | b cell assays |
| subject species: | Mus musculus |
| fullName: |
Hiroyuki Tahara
Kentaro Ide
Nabin Bahadur Basnet
Yuka Tanaka
Haruo Matsuda
Hiromu Takematsu
Yasunori Kozutsumi
Hideki Ohdan
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| method: |
biological activity
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| name: |
Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice.
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| description: |
The in vivo toxicity to epitope-expressing thymocytes and pancreatic islets from CMAH+/+ mice is detected in immunized cytidine monophospho–N-acetylneuraminic acid hydroxylase (CMAH) deficient (CMHA-/-) mice, seen as a failure to detect engrafted cells. Also in vitro Ab-mediated cytotoxicity is detected. In contrast, immunized CMAH-/- mice did not reject vascularized NeuGc-expressing heart grafts, even if exogenous rabbit complement was added.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
