Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

Title:

Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

identifier:	1791632
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group host organism:Chlorocebus aethiops
aggregation:	instance of dataset
availability:	available
primaryPublications:	19563260

study type:	b cell assays
subject species:	Sus scrofa Landrace X Large White

fullName:	Kerry A Daly Ann M Stewart-Akers Hidetaka Hara Mohamed Ezzelarab Cassandra Long Kevin Cordero Scott A Johnson David Ayares David K C Cooper Stephen F Badylak

method:	ELISA

name:	Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.
description:	Anti-Gal IgG production in monkeys that received the WT pig transplant was higher than the antibody response in those that received GalKO or allogeneic SIS-ECM material, which showed no anti-Gal IgG response. IgM anti-epitope levels were not different among the groups, nor were the responses in those animals that received a second transplant to test for sensitization. The existence of a positive IgG response to the epitope did not influence the outcome of the transplant process, as all groups were equal in regard to anti-pig (other than epitope) antibodies, cellular toxicity to pig PBMC, expression of cytokines, histological and macroscopic appearance of the graft, and host remodeling response.

name:	iedb
homePage:	http://www.iedb.org

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