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Title: Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein.
identifier: 1792261
description:
epitope description:oxidised cardiolipin
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 11181467
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1016217
landingPage: http://www.iedb.org/assay/1792261
type:
Literature
publicationVenue:
Circulation
dates:
2001
study type: b cell assays
subject species: Bos taurus
fullName:
S Hö
rkkö
L Mo
D W Branch
V L Woods Jr
W Palinski
P P Chen
J L Witztum
method:
antigen inhibition
name:
Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein.
description:
All 22 serum samples demonstrated IgG binding to the epitope in a direct chemiluminescent immunoassay. Immunoassay of protein A-purified IgG fractions from sera of 4 APS patients showed similar results. The epitope inhibited APS serum IgG binding to ß2GP1 protein and to copper-oxidized LDL (CuOx-LDL). Anti-ß2GP1 Ab showed that substantial amounts of human b2GP1 (from the APS serum) bound to the epitope. All 22 APS serum bound to the epitope covalently bound to ß2GP1 protein.

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