Reactivity profile of anti-factor VIII antibodies with designed synthetic peptides mimicking epitopes of the C2 and a1 domains.

Title:

Reactivity profile of anti-factor VIII antibodies with designed synthetic peptides mimicking epitopes of the C2 and a1 domains.

identifier:	1769372
description:	epitope description:LNSSSMPLGMESKAISAAC host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	18422780

study type:	b cell assays
subject species:

fullName:	D G Chaves C Velloso-Rodrigues V Moreau C Nguyen S Villard A R Belisá rio C Granier M M Santoro

method:	antigen inhibition

name:	Reactivity profile of anti-factor VIII antibodies with designed synthetic peptides mimicking epitopes of the C2 and a1 domains.
description:	The epitope was designed to display the surface residues LNS and MPL of factor VIII. The epitope was C-terminally amidated to create a cyclic peptide. The epitope inhibited binding of the patient sera to factor VIII in an ELISA assay.

name:	iedb
homePage:	http://www.iedb.org

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