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Title: An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.
identifier: 1769507
description:
epitope description:R660, Y661, Y665
antigen name:A disintegrin and metalloproteinase with thrombospondin motifs 13
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 20032502
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1019053
landingPage: http://www.iedb.org/assay/1769507
type:
Literature
publicationVenue:
Blood
dates:
2010
study type: b cell assays
subject species: Homo sapiens
fullName:
Wouter Pos
James T B Crawley
Rob Fijnheer
Jan Voorberg
David A Lane
Brenda M Luken
method:
immunoprecipitation
name:
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.
description:
The patient antiserum binds to ADAMTS13, but not when the epitopic residues are substituted with alanine.

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