Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect.

Title:

Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect.

Dataset

identifier:	1769600
description:	epitope description:HQIALRMEVLGCEAQD antigen name:Coagulation factor VIII host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10520041

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011959
landingPage:	http://www.iedb.org/assay/1769600

Publication

type:	Literature
publicationVenue:	Br J Haematol
dates:	1999

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	K Nogami M Shima H Nakai I H Suzuki S Morichika M Shibata E L Saenko D Scandella J C Giddings A Yoshioka

Data Type

method:	antigen inhibition

Study

name:	Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect.
description:	Binding of the IgG from haemophilia A patients to factor VIII was inhibited by the epitope as measured by Bethesda assay. Residues R6, C11 and E12 were found to be important for epitope inhibition by glycine substitution. The patient IgG also bound the epitope in direct binding ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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