Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746.

Title:

Dataset

identifier:	1768574
description:	epitope description:EVVTGSPRGDSQSS antigen name:von Willebrand factor host organism:Oryctolagus cuniculus New Zealand White antibody name:152B
aggregation:	instance of dataset
availability:	available
primaryPublications:	2453507

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1009709
landingPage:	http://www.iedb.org/assay/1768574

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	1988

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S Berliner K Niiya J R Roberts R A Houghten Z M Ruggeri

Data Type

method:	antigen inhibition

Study

name:	Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746.
description:	The antigen inhibited the binding of the epitope-specific antiserum to the antigen. The antiserum also recognized the antigen in direct binding assay measured by ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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