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Title: Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.
identifier: 1768851
description:
epitope description:SSPPCE
antigen name:Thyrotropin receptor
host organism:Mus musculus NMRI
antibody name:IRI-SAb2
aggregation:
instance of dataset
availability:
available
primaryPublications: 19066298
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1014206
landingPage: http://www.iedb.org/assay/1768851
type:
Literature
publicationVenue:
J Clin Endocrinol Metab
dates:
2009
study type: b cell assays
subject species: Homo sapiens
fullName:
Yumiko Mizutori
Chun-Rong Chen
Francesco Latrofa
Sandra M McLachlan
Basil Rapoport
method:
biological activity
name:
Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.
description:
The epitope was deduced.
Epitope-specific mAb stimulated cAMP production in CHO cells expressing the human TSHR. Preincubation of the mAb with soluble TSHR A subunit (residues 22-289) inhibited the stimulatory activity of the mAb.

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