Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.

Dataset

identifier:	1768853
description:	epitope description:R503, Y506, R508, P511 antigen name:Coagulation factor VIII host organism:Mus musculus antibody name:mAb413
aggregation:	instance of dataset
availability:	available
primaryPublications:	9374501

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017106
landingPage:	http://www.iedb.org/assay/1768853

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	1997

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	I M Lubin J F Healey R T Barrow D Scandella P Lollar

Data Type

method:	biological activity

Study

name:	Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
description:	Inhibition of fVIII activity by the epitope specific monoclonal antibody was measured by Bethesda titer. Inhibition was disrupted by mutating residues R503, Y506, or R508 to alanine.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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