Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.

Dataset

identifier:	1768855
description:	epitope description:Y506, S507, R508, P511, V514, F520, I527 antigen name:Coagulation factor VIII host organism:Homo sapiens antibody name:JM, RC, NS, WD, CHA
aggregation:	instance of dataset
availability:	available
primaryPublications:	9374501

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017106
landingPage:	http://www.iedb.org/assay/1768855

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	1997

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	I M Lubin J F Healey R T Barrow D Scandella P Lollar

Data Type

method:	biological activity

Study

name:	Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
description:	Inhibition of fVIII activity by the epitope specific sera antibodies were measured by Bethesda titer. Inhibition was disrupted by mutating residues Y506, S507, R508, P511, V514, F520, I527 to alanine.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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