Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice.

Title:

Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice.

identifier:	1768922
description:	epitope description:KWNEANR antigen name:Coagulation factor VIII host organism:Mus musculus Xenomouse antibody name:8E3, 22B6
aggregation:	instance of dataset
availability:	available
primaryPublications:	17598006

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Gé raldine Lavigne-Lissalde Sé bastien Lacroix-Desmazes Bharath Wootla Catherine Tarrade Jean-Franç ois Schved Srini V Kaveri Claude Granier Sylvie Villard-Saussine

method:	antigen inhibition

name:	Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice.
description:	This minimal epitope was identified by overlapping studies. The epitope inhibited the epitope-specific mAb binding to the FVIII protein. The epitope had an IC₅₀ of 5±0.09 µg/ml for the mAbs.

name:	iedb
homePage:	http://www.iedb.org

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