Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.

Title:

Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.

Dataset

identifier:	1768898
description:	epitope description:SPRKGSFT antigen name:A disintegrin and metalloproteinase with thrombospondin motifs 13 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16953270

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017975
landingPage:	http://www.iedb.org/assay/1768898

Publication

type:	Literature
publicationVenue:	Thromb Haemost
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Brenda M Luken Ellen A M Turenhout Paul H P Kaijen Mascha J Greuter Wouter Pos Jan A van Mourik Rob Fijnheer Jan Voorberg

Data Type

method:	immunoprecipitation

Study

name:	Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.
description:	Replacing the epitope in the ADAMTS13 protein did not affect the binding of patient-derived IgG to the protein.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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