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Title: Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients.
identifier: 1768937
description:
epitope description:SSISSEDILAVLQRDDVRQYLRQYLMGP
antigen name:Collagen alpha-1(XVII) chain
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 14962097
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017261
landingPage: http://www.iedb.org/assay/1768937
type:
Literature
publicationVenue:
J Invest Dermatol
dates:
2004
study type: b cell assays
subject species: Homo sapiens
fullName:
Giovanni Di Zenzo
Fabiana Grosso
Michela Terracina
Feliciana Mariotti
Ornella De Pità
Katsushi Owaribe
Alessandro Mastrogiacomo
Francesco Sera
Luca Borradori
Giovanna Zambruno
method:
western blot
name:
Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients.
description:
This epitope, initially selected by immunopanning of a phage-displayed library of random fragments of human BP180 with one or more sera from bullous pemphigoid (BP) patients, was tested in plaque dot-blot with 57 BP patients, 64 normal healthy individuals (NHI) and 17 pemphigus controls. This epitope was recognized with significantly higher frequency by BP sera than by NHI control sera. It was not recognized by pemphigus controls.

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