Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia B(M) by synthetic peptides.

Title:

Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia B(M) by synthetic peptides.

Dataset

identifier:	1769212
description:	epitope description:ITQSTQSFNDFTRVV antigen name:Coagulation factor IX host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	10876041

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1010369
landingPage:	http://www.iedb.org/assay/1769212

Publication

type:	Literature
publicationVenue:	Peptides
dates:	2000

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	I Takahashi M Sano T Watanabe H Saito

Data Type

method:	western blot

Study

name:	Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia B(M) by synthetic peptides.
description:	Binding of the monoclonal antibody to the epitope was disrupted by substitutions at positions F8 for D, E, G, K, R, T or V, at N9 for D, E, F, I, K, L, P, V, or Y, at D10 for C, E, F, I, K, L, M, P, Q, R, S, T, V, W, or Y and at F11 for P.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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