A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens.

Title:

A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens.

identifier:	1769989
description:	epitope description:SQTTANPSCPEGT antigen name:Protein LOC100911572 host organism:Rattus norvegicus Wistar Kyoto
aggregation:	instance of dataset
availability:	available
primaryPublications:	15034074

study type:	b cell assays
subject species:	Rattus norvegicus

fullName:	Jean Wu Jon Arends Jason Borillo Cindy Zhou Justin Merszei John McMahon Ya-Huan Lou

method:	ELISA

name:	A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens.
description:	The epitope sequence was cited in Wu et al. Kidney Int. 2003 Oct 64(4):1292-301 [PMID: 12969147]. Antibodies were eluted from kidneys of epitope-immunized rats. Amino acids P10, G12, and T13 were identified as critical residues by alanine substitutions.

name:	iedb
homePage:	http://www.iedb.org

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