Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1019178 |
| landingPage: |
http://www.iedb.org/assay/1770508 |
| type: |
Literature
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| publicationVenue: |
PLoS Pathog
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| dates: |
2010
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| study type: | b cell assays |
| subject species: | Influenza A virus (A/Hong Kong/1/1968(H3N2)) |
| fullName: |
Taia T Wang
Gene S Tan
Rong Hai
Natalie Pica
Erin Petersen
Thomas M Moran
Peter Palese
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| method: |
biological activity
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| name: |
Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins.
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| description: |
The epitope was deduced.
Epitope-specific mAb was evaluated for their ability to neutralize H3 influenza viruses by microneutralization assay and plaque reduction assay. The mAb was able to prevent infection (not simply reduce plaque size) by several H3 viruses A/HK/1968, A/BJ/1992,A/Pan/99, A/Bris/07, A/NY/08 while representative H1, H4 and H7 viruses were not neutralized. While the mAb was not able to inhibit HA-induced hemagglutination, it was determined to inhibit the low pH fusion of A/HK/1968 virus with chicken red blood cells.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
