Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1018824 |
| landingPage: |
http://www.iedb.org/assay/1770476 |
| type: |
Literature
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| publicationVenue: |
Blood
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| dates: |
2007
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| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Zhihong Liu
Vincent S Stoll
Peter J Devries
Clarissa G Jakob
Nancy Xie
Robert L Simmer
Susan E Lacy
David A Egan
John E Harlan
Richard R Lesniewski
Edward B Reilly
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| method: |
x-ray crystallography
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| name: |
A potent erythropoietin-mimicking human antibody interacts through a novel binding site.
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| description: |
The epitope of ABT007 Fab on the human EPO receptor (EPOR) was determined from the crystal structure of the complex. EPOR exists as a preformed dimer, however, monomeric soluble domain of the receptor was used for crystallization. The crystallographic unit [PDB: 2JIX] contains 3 EPOR monomers (chains B, C, E), and 3 Fabs: (1) chains A (light) and F (heavy), (2) G (light) and D (heavy), and (3) L (light) and H (heavy). The Fabs interact with EPOR as follows: Fab(1) with C chain (both Fab chains contact) and B (light chain contacts only); Fab(2) with chain E (both Fab chains contact) and chain C (light chain contacts only); Fab(3) with chain E (light chain contacts only). Since the contacts are different, two complexes were curated: Fab(1) - chain C and Fab(2) - chain E.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
