Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody.

Title:

Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody.

identifier:	1770520
description:	epitope description:C74, P75, T76, M77, G78, E79, G104, C105, G106, L107, G109, K110 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:E53
aggregation:	instance of dataset
availability:	available
primaryPublications:	19713934

study type:	b cell assays
subject species:	West Nile virus

fullName:	Mickaë l V Cherrier Bä rbel Kaufmann Grant E Nybakken Shee-Mei Lok Julia T Warren Beverly R Chen Christopher A Nelson Victor A Kostyuchenko Heather A Holdaway Paul R Chipman Richard J Kuhn Michael S Diamond Michael G Rossmann Daved H Fremont

method:	x-ray crystallography

name:	Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody.
description:	The entire sequence of the E53 epitope is conserved between WNV and all four DENV serotypes with the exception of residue M77, which is a glutamine in DENV. The eptiope of E53 Fab on the WNV envelope glycoprotein was determined from the crystal structure of the complex.

name:	iedb
homePage:	http://www.iedb.org

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